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10–12 When PD-1 inhibitors are combined with CTLA-4 inhibitors, such as nivolumab and tremelimumab, for the treatment of unresectable hepatocellular carcinoma (uHCC), the reported rates of ALT, AST, and TBIL elevations were 9.28–16.33%, 12.37–20.41%, and 5.15%, respectively